NAICS 325414

Overview

The North American Industry Classification System (NAICS) is the federal standard for classifying business establishments to support collection, analysis, and publication of U.S. economic statistics. Developed jointly by the United States, Canada, and Mexico and adopted in 1997 to replace the SIC system, the most recent revision is the 2022 NAICS. ¹
U.S. Industry NAICS 325414 is defined by the Census Bureau as establishments primarily engaged in manufacturing vaccines, toxoids, blood fractions, and culture media of plant or animal origin, excluding diagnostic uses. It is part of NAICS subsector 3254, Pharmaceutical and Medicine Manufacturing, and is distinct from in‑vitro diagnostic substances and non‑biological pharmaceutical preparations per official cross‑references. ²

See also on G2X:

• G2X — NAICS 325414 overview
• G2X — NAICS 325413 In‑Vitro Diagnostic Substance Manufacturing
• G2X — NAICS 325412 Pharmaceutical Preparation Manufacturing

What this NAICS covers

• Manufacturing human‑use vaccines (non‑diagnostic). ²
• Manufacturing toxoids and similar antigenic biologicals (non‑diagnostic). ²
• Manufacturing blood fractions and blood‑derived products (e.g., plasma derivatives). ²
• Manufacturing culture media of plant or animal origin for non‑diagnostic purposes. ²
• Biological product manufacturing activities classified within pharmaceutical and medicine manufacturing, where the outputs are not in‑vitro diagnostic substances. ²
• Production of biologicals distinguished from pharmaceutical preparations and in‑vitro diagnostics by NAICS cross‑references. ²

Related NAICS and PSC codes

Boundary notes and exclusions

• In‑vitro diagnostic substances are excluded; such products are classified under NAICS 325413. ²
• Pharmaceutical preparations (except biological and in‑vivo diagnostic substances) are excluded; such products are classified under NAICS 325412. ²
• Packaging or distribution activities not integral to manufacturing: classification guidance is not specified by official sources ²

Frequently asked questions

• What does NAICS 325414 include?
  It covers establishments primarily engaged in manufacturing vaccines, toxoids, blood fractions, and culture media of plant or animal origin when these products are not for diagnostic use. Cross‑references delineate related industries to avoid overlap. ²

• How is NAICS used in federal contracting and reporting?
  Although designed for statistical purposes, NAICS is frequently used for administrative, regulatory, and contracting activities across the federal government, including setting eligibility thresholds and structuring market research. ⁵

• How does NAICS 325414 differ from NAICS 325413?
  NAICS 325414 covers biological products excluding diagnostics, while NAICS 325413 is limited to in‑vitro diagnostic substances used in tests and devices (e.g., test tubes, instruments). The cross‑references explicitly separate these activities. ²

• Which Census products have adopted the 2022 NAICS vintage?
  Census began publishing data on the 2022 NAICS basis with the 2022 Economic Census First Look in January 2024 and plans full transition of remaining programs by the end of 2027, with limited exceptions noted by Census. ³

• What is the SBA small business size standard for NAICS 325414?
  Size standards are maintained by SBA and may change; consult SBA’s current Size Standards table or API for the official threshold associated with NAICS 325414. Not specified by official sources ⁶

Useful resources

• G2X — NAICS 325414 overview
• Census — Economic Census: NAICS Codes & Understanding Industry Classification Systems. ¹
• Census — NAICS Sector 31–33 archive page with NAICS 325414 definition and cross‑references. ²
• Census — Implementation of the 2022 NAICS (transition timeline and coverage). ³

References

1. U.S. Census Bureau — Frequently Asked Questions about Industry and Occupation (NAICS history and 2022 reference). https://www.census.gov/topics/employment/industry-occupation/about/faq.html
2. U.S. Census Bureau — NAICS Sector 31–33 archive page including NAICS 325414 definition and cross‑references. https://www.census.gov/naics/resources/archives/sect31-33.html
3. U.S. Census Bureau — Implementation of the 2022 NAICS. https://www.census.gov/library/reference/code-lists/naics/2022/implementation-timeline.html
4. Acquisition.gov — Product and Service Code (PSC) Manual (current files). https://www.acquisition.gov/psc-manual/all
5. U.S. Census Bureau — Schedule B Codes, NAICS and NAPCS: The Similarities and Differences. https://www.census.gov/newsroom/blogs/global-reach/2018/09/schedule_b_codesna.html
6. U.S. Small Business Administration — Small Business Size Standards (current datasets and API). https://web.data.sba.gov/en/dataset/small-business-size-standards